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Objective To understand the relationship between negative life events and suicide ideation,and how it was influenced by the mediating effect of depression.Methods 1145 college students from one university were selected using cluster sampling.Both Symptom Check List (SCL-90) and Qestionnaire were administered to measure depression and suicide ideation in the past week and on the prevalence of negative life events and related information.Recent negative life events would include physical illness,academic problem,financial problem and interpersonal conflict etc.Multiple logistic regressions were used to identify the mediating effect of depression.Results Physical illness (OR=2.5,P=0.028),interpersonal conflict (OR=7.2,P=0.002) and financial problem (OR =1.6,P =0.026) were significantly associated with suicide ideation,but academically-related problems did not seem to be significantly associated with suicide ideation (OR=1.8,P=0.090).After adjusted for depression,both physical illness and interpersonal conflicts were not but financial problem remained significantly associated with suicide ideation (OR =1.7,P =0.014).Our data showed that depression fully mediated the relationship between physical illness,interpersonal conflict and suicide ideation,but did not mediate the relationship between financial problem and suicide ideation.Conclusion Depression played different mediating roles between different negative life events and suicide ideation.The findings from this study might be able to provide some clues for the prevention interventions on college students.
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Objective To explore the influence of occupational stress and negative life events that occur during pregnancy on different types of low birth weight (LBW). Methods 438 singleton LBW infants (birth weight of less than 2500 g and their pregnancy term from 28 to 42 weeks) were selected as case group, and they were further divided into symmetric LBW infants (337 cases) and asymmetric LBW infants (101 cases). According to situation of each LBW infant, a singleton with full term and normal birth weight was selected as control group matched by sex, pregnancy term, time during delivery and types of hospital.All of their mothers were inquired by well trained investigators on their socio-demographic characteristics, occupational stress, and negative life events that occurred in different pregnancy term. After controlling for mother's age, occupation,education level and family income, multinomial logistic regression was employed to asses the influence of occupational stress and negative life events on symmetric LBW and asymmetric LBW. Results Compared with those using low technical skills, mothers with high technical skill utilization significantly decreased the risk of laboring both symmetric LBW ( OR = 0.69, 95 ％ CI:0.49-0.98) and asymmetric LBW (OR = 0.53,95％CI: 0.31-0.89). Compared with those without exposure to negative life events, mothers with negative life event score ≥ 3 in the whole duration of pregnancy had significantly increased the risk of delivering symmetric LBW ( OR = 2.30, 95％ CI : 1.08-4.88), mothers with negative life event score ≥3 in the middle three months of pregnancy, ≥3 in the last three months of pregnancy, = 2 and ≥3 in the whole duration of pregnancy had significantly increased the risk of delivering asymmetric LBW, and their OR (95 ％ CI ) was 8.85 (1.97-39.68), 3.80 ( 1.40-10.29 ),3.58(1.33-9.66) and 3.48 (1.32-9.13), respectively. Conclusion Occupational stress and negative life events might produce different influence on symmetric LBW and negative life events that occurr in the different terms of pregnancy had different impact on symmetric LBW and asymmetric LBW.
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Compared with 165 subjects without coronary artery disease(CAD),125 CAD pa-tients diagnosed bycoronary arteriography were investigated on the possibld relationship among psy-choosocial factors,including occupation,negative life events,type A behavior,and indexes of bloodlipid and blood rheology.The results showed that occupation type was one of the significantly correatesto the indexes of blood-lipid metabalism and blood rheology.The changes of neuroendocrinology andblood rheology following the occurrence of negative life events were correlated with the onset of lethalCAD.The physical and chemical indexes of hematology observed in subjects with Type A behaviorwere associated with atherogenesis and the pathogenesis of CAD.
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Objective To investigate the relationship between post-cerebral infarction depression and negative life events and the therapeutic effect on depression. Methods 162 patients with cerebral infarction were assigned to negative life event affecting group (A group,85) and non- negative life event affecting group (B group,77), and then assessed condition of depression by self-rating depression scale( SDS )and Hamilton rating scale (HRSD). The curative effect before and after therapy of fluoxetine(20 mg/d?4 w) was compared. Results The incidence of depression are 56.5% in group A and 36.4% in group B respectively. The difference is significantly( P